Piezoelectrostatic Catalysis of the Azide–Alkyne Huisgen Cycloaddition
Electric fields are increasingly recognized for their role as 'smart reagents' that can trigger or accelerate chemical reactions. Expanding upon this concept, our research introduces an innovative method that exploits electric fields induced by ultrasound on piezoelectric nanoparticles to facilitate the azide-alkyne Huisgen cycloaddition in nonaqueous environments. The intense electric field generated around the BaTiO<sub>3</sub> nanoparticles, as supported by density functional theory calculations, provides the suitable conditions necessary to trigger the cycloaddition of the alkyne-functionalized nanoparticles and the azide present in the solution. To quantitatively assess the occurrence of the click cycloaddition reaction at the nanoparticle surface interface, we tacked the azide with either an electroactive ferrocene moiety or with gold nanoparticles, which act as surface Raman enhancers. These experiments not only provide experimental validation of our approach, but also highlights the potential of piezoelectrostatic catalysts in enhancing the scalability of electrostatic catalysis.
Authors
- Kishan Thodkar (ORCID: https://orcid.org/0000-0002-5178-7291)
- Chiara Gattinoni (ORCID: https://orcid.org/0000-0002-3376-6374)
- Bradley J. Nelson (ORCID: https://orcid.org/0000-0001-9070-6987)
- Salvador Pané (ORCID: https://orcid.org/0000-0003-0147-8287)
- Qiao Tang (ORCID: https://orcid.org/0000-0003-4928-5417)
- Carlos Franco (ORCID: https://orcid.org/0000-0003-3385-2851)
- Jiang Wu (ORCID: https://orcid.org/0000-0001-7227-6426)
- Xiangzhong Chen (ORCID: https://orcid.org/0000-0002-2294-7487)
- Roger Sanchis‐Gual (ORCID: https://orcid.org/0000-0002-9096-7930)
- Josep Puigmartí‐Luis (ORCID: https://orcid.org/0000-0002-7510-9815)
- Ni Qin (ORCID: https://orcid.org/0000-0001-7643-8728)
- Semih Sevim (ORCID: https://orcid.org/0000-0003-1461-1606)
- Ismael Díez‐Pérez (ORCID: https://orcid.org/0000-0003-0513-8888)
- Andrea Veciana (ORCID: https://orcid.org/0000-0003-0060-0949)
- Carlos Corral-Casas (ORCID: https://orcid.org/0000-0002-1824-9504)
- Hao Ye (ORCID: https://orcid.org/0000-0003-3526-9627)
Institutions
- Institució Catalana de Recerca i Estudis Avançats (ES)
- King's College London (GB)
- Fudan University (CN)
- ETH Zurich (CH)
- Division of Materials Science and Engineering (AU)
- Trinity House (GB)
- Yiwu Science and Technology Research Institute (CN)
- Imperial College London (GB)
- Carrier (United States) (US)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1021/jacs.4c15681
- Citations
- 7
- Primary Topic
- Innovative Microfluidic and Catalytic Techniques Innovation
- Type
- article
- Field-Weighted Citation Impact
- 4.72
Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- China Postdoctoral Science Foundation
- China Scholarship Council
- Ministerio de Ciencia y Tecnología
- Engineering and Physical Sciences Research Council
- Biotechnology and Biological Sciences Research Council
- European Research Council
- Fundamental Research Funds for the Central Universities
- HORIZON EUROPE Marie Sklodowska-Curie Actions