Age-Related Changes in Brain Structure in Pediatric Chronic Kidney Disease
In this case-control study, age-related neurodevelopmental differences were observed in pediatric patients with CKD compared with healthy peers. Reductions in cerebellar volume were associated with cognitive deficits and lower kidney function. These findings underscore the importance of monitoring neurodevelopmental trajectories in children with CKD, as early interventions may be necessary to mitigate cognitive impairments associated with CKD.
Authors
- Anne E. Dawson (ORCID: https://orcid.org/0000-0003-4423-8558)
- Joseph L. Alge (ORCID: https://orcid.org/0000-0002-2491-1066)
- Ellen van der Plas (ORCID: https://orcid.org/0000-0002-7490-6636)
- Lyndsay A. Harshman (ORCID: https://orcid.org/0000-0003-4952-8132)
- Camille Wilson (ORCID: https://orcid.org/0000-0003-3226-7845)
- Jeffrey D. Dawson (ORCID: https://orcid.org/0000-0003-2709-0360)
- Brian Becknell (ORCID: https://orcid.org/0000-0002-2750-4415)
- Eric E. Nelson (ORCID: https://orcid.org/0000-0002-3376-2453)
Institutions
- University of Iowa (US)
- Arkansas Children's Hospital (US)
- Nationwide Children's Hospital (US)
- University of Iowa Health Care (US)
- The Ohio State University (US)
- University of Arkansas for Medical Sciences (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1001/jamanetworkopen.2024.57601
- Citations
- 4
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 13.98
Funders
- Children’s Hospital of Wisconsin Research Institute
- Upsher-Smith
- National Cancer Institute
- National Institute of Diabetes and Digestive and Kidney Diseases