Activity-based chemical proteomics reveals caffeic acid ameliorates pentylenetetrazol-induced seizures by covalently targeting aconitate decarboxylase 1
In summary, this study elucidates, for the first time, the potential antiepileptic targets and mechanism of action of caffeic acid using the ABPP strategy. Our study provides evidence supporting the utilization of caffeic acid as a promising therapeutic agent for treating epilepsy and neuroinflammation-related disorders.
Authors
- Wenhua Kuang (ORCID: https://orcid.org/0000-0002-5005-2330)
- Guohua Zeng (ORCID: https://orcid.org/0000-0002-3790-6434)
- Letai Yi
- Qiaoli Shi (ORCID: https://orcid.org/0000-0003-2041-8001)
- Peili Wang (ORCID: https://orcid.org/0000-0002-1440-6613)
- Dandan Liu (ORCID: https://orcid.org/0000-0002-0880-9686)
- Jigang Wang (ORCID: https://orcid.org/0000-0002-0575-0105)
- Ying Zhang (ORCID: https://orcid.org/0000-0001-8665-2744)
- Jichao Sun
- Di Gu
- Huan Tang (ORCID: https://orcid.org/0000-0002-9098-0684)
- Guanjun Li
- Junzhe Zhang (ORCID: https://orcid.org/0000-0002-4299-5566)
- Xin Peng (ORCID: https://orcid.org/0000-0003-2620-1188)
- Ling Huang (ORCID: https://orcid.org/0000-0003-0420-6017)
Institutions
- Zhejiang Chinese Medical University (CN)
- Henan University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Southern University of Science and Technology (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Ningbo No. 2 Hospital (CN)
- Xiyuan Hospital (CN)
- China Academy of Chinese Medical Sciences (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Shenzhen Second People's Hospital (CN)
- Inner Mongolia Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1186/s12964-024-01739-y
- Citations
- 8
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.62
Funders
- National Natural Science Foundation of China
- China Academy of Chinese Medical Sciences