Prevalence of HSV Genomic Signatures Among Acanthamoeba Hosts and Contaminated Lens Cases: A Molecular and Clinical Study
This study is the first to identify HSV-positive genomic signatures in clinical AK isolates and/or contact lens cases. Taken together, the high prevalence of HSV genomic signatures in both amebic hosts and lens cases, might signal an unrecognized Acanthamoeba-HSV association and the need for reassessing current management.
Authors
- A Alfonso
- Paula A. Sepulveda-Beltran (ORCID: https://orcid.org/0000-0003-0458-5838)
- Guillermo Amescua (ORCID: https://orcid.org/0000-0003-2854-0626)
- Jaime D. Martinez (ORCID: https://orcid.org/0000-0001-8307-7465)
- Harry W. Flynn (ORCID: https://orcid.org/0000-0002-9990-7467)
- Juan Manuel Andrade Navia (ORCID: https://orcid.org/0000-0001-9644-0040)
- Darlene Miller (ORCID: https://orcid.org/0000-0002-4756-2030)
- Heather A. Durkee (ORCID: https://orcid.org/0000-0002-5476-5813)
- Eduardo C. Alfonso (ORCID: https://orcid.org/0000-0002-3391-922X)
- Jorge Maestre-Mesa (ORCID: https://orcid.org/0000-0002-0604-9812)
- Jean-Marie Parel
- Felipe Echeverri-Tribin
- Salomon Merikansky
Institutions
- University of Miami (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1167/iovs.66.2.4
- Primary Topic
- Legionella and Acanthamoeba research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Research to Prevent Blindness
- Henri and Flore Lesieur Foundation
- National Institutes of Health