Lamp2 Deficiency Enhances Susceptibility to Oxidative Stress–Induced RPE Degeneration
Lamp2 deficiency, when combined with oxidative stress, leads to RPE degeneration in vivo. Lysosomal dysfunction also promotes macrophage engraftment and triggers neurotoxic inflammation.
Authors
- Keijiro Ishikawa (ORCID: https://orcid.org/0000-0002-4590-4471)
- Yusuke Murakami (ORCID: https://orcid.org/0000-0002-3761-1732)
- Toshio Hisatomi (ORCID: https://orcid.org/0000-0003-2552-9595)
- Ziming Xu (ORCID: https://orcid.org/0000-0002-0002-7874)
- Shoji Notomi (ORCID: https://orcid.org/0000-0002-7935-4244)
- Yosuke Fukuda (ORCID: https://orcid.org/0000-0002-7087-1595)
- Yusuke Maehara (ORCID: https://orcid.org/0009-0002-9797-951X)
- Guannan Wu
- Tao Yan (ORCID: https://orcid.org/0000-0002-8929-015X)
- Koh-Hei Sonoda
- Huanyu Zhao
Institutions
- Kyushu University (JP)
- Fukuoka University (JP)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1167/iovs.66.2.2
- Citations
- 1
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.35