Host factor PLAC8 is required for pancreas infection by SARS-CoV-2
Our data indicate the human pancreas as a SARS-CoV-2 target with plausible signs of injury and demonstrate that the host factor PLAC8 is required for SARS-CoV-2 pancreatic infection, thus defining new target opportunities for COVID-19-associated pancreatic pathogenesis.
Authors
- Charlotte Steenblock (ORCID: https://orcid.org/0000-0002-9635-4860)
- Hanna Dietenberger
- Sandra Heller (ORCID: https://orcid.org/0000-0002-8704-2646)
- Patricia Gallego (ORCID: https://orcid.org/0000-0002-6114-7407)
- Catalina Crespı́ (ORCID: https://orcid.org/0000-0003-0781-9708)
- Lesly Ibargüen-González (ORCID: https://orcid.org/0000-0002-1587-5171)
- Carles Barceló (ORCID: https://orcid.org/0000-0003-2551-2136)
- Alejandro P. Ugalde (ORCID: https://orcid.org/0000-0003-2522-0627)
- Alexander Kleger (ORCID: https://orcid.org/0000-0003-0592-5232)
- Eugenia Cisneros‐Barroso (ORCID: https://orcid.org/0000-0002-4109-4635)
- Marta L. DeDiego (ORCID: https://orcid.org/0000-0002-7888-7372)
- Israel Fernández‐Cadenas (ORCID: https://orcid.org/0000-0003-4821-2363)
- Darío López-García (ORCID: https://orcid.org/0000-0002-5990-8940)
- Gabriel Bretones (ORCID: https://orcid.org/0000-0002-1521-5544)
- Julieth Mena-Guerrero
- Sayoa Alzate-Piñol
- Thomas F.E. Barth (ORCID: https://orcid.org/0000-0002-3379-6311)
Institutions
- Universitat de Vic - Universitat Central de Catalunya (ES)
- Universitat Oberta de Catalunya (ES)
- Universidad de Oviedo (ES)
- Hospital de Sant Pau (ES)
- Hospital Son Llatzer (ES)
- Centro Nacional de Biotecnología (ES)
- Health Research Institute of the Balearic Islands (ES)
- Hospital Universitario Son Espases (ES)
- University Hospital Ulm (DE)
- University Hospital Carl Gustav Carus (DE)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1038/s43856-025-00745-6
- Citations
- 1
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Fundació la Marató de TV3
- University of Victoria
- European Commission
- Deutsche Forschungsgemeinschaft
- Technische Universität Dresden
- Ministerio de Ciencia e Innovación
- Universidad de Oviedo
- Universität Ulm
- Universitat Oberta de Catalunya
- Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona
- Govern de les Illes Balears
- Instituto de Salud Carlos III
- European Regional Development Fund
- Agencia Estatal de Investigación
- Centro Nacional de Biotecnología