Multicompartment Polyion Complex Micelles Based on Triblock Polypept(o)ides Mediate Efficient siRNA Delivery to Cancer‐Associated Fibroblasts for Antistromal Therapy of Hepatocellular Carcinoma (Adv. Mater. 41/2024)
siRNA co-Delivery With a novel identified target of cancer-associated fibroblast-derived microfibrillar-associated protein 5 (MFAP-5), ABC-triblock copolymer based multicompartment polyion complex micelle (PICM) deliver siRNA against MFAP-5 and the cationic amphiphilic drug desloratadine simultaneously. The codelivery of desloratadine facilitates intracellular siRNA delivery, resulting in knockdown of MFAP-5 and significantly reduce tumor burden in a mice model of hepatocellular carcinoma. More details can be found in article number 2404784 by Heyang Zhang, Leonard Kaps, Matthias Barz, and co-workers.
Authors
- Koen Raemdonck (ORCID: https://orcid.org/0000-0002-9807-4715)
- Vanessa Bolduan
- Zhuqing Dai
- Barbara Schrörs (ORCID: https://orcid.org/0000-0001-9758-250X)
- Stephan Grabbe (ORCID: https://orcid.org/0000-0002-6863-8719)
- Özlem Akilli‐Öztürk
- Kaloian Koynov (ORCID: https://orcid.org/0000-0002-4062-8834)
- Feyza Durak (ORCID: https://orcid.org/0000-0003-4853-4776)
- Matthias Bros (ORCID: https://orcid.org/0000-0002-4662-0542)
- Leonard Kaps (ORCID: https://orcid.org/0000-0002-4782-8003)
- Bram Bogaert (ORCID: https://orcid.org/0000-0003-3936-7187)
- Jenny Schunke
- Gabriela Schäfer (ORCID: https://orcid.org/0000-0002-5214-9830)
- Matthias Barz (ORCID: https://orcid.org/0000-0002-1749-9034)
- Mustafa Diken (ORCID: https://orcid.org/0009-0005-4391-4042)
- David Schwiertz (ORCID: https://orcid.org/0000-0002-4387-5064)
- Paul M. Schneider (ORCID: https://orcid.org/0000-0003-2776-4441)
- Jörn M. Schattenberg (ORCID: https://orcid.org/0000-0002-4224-4703)
- Lin Jian
- Heyang Zhang (ORCID: https://orcid.org/0000-0002-3307-1783)
- Leon Simić
Institutions
- Leiden University (NL)
- Johannes Gutenberg University Mainz (DE)
- Ghent University (BE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Max Planck Institute for Polymer Research (DE)
- Centre for Human Drug Research (NL)
- Saarland University (DE)
Publication Details
- Journal
- Advanced Materials
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/adma.202470332
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00