Soluble Aβ pathology predicts neurodegeneration and cognitive decline independently on p‐tau in the earliest Alzheimer's <i>continuum</i> : Evidence across two independent cohorts
We assessed brain atrophy and cognitive decline in asymptomatic individuals. Aβ biomarkers predicted MTL atrophy independently of p-tau. Our results underscore the importance of undertaking Alzheimer's preclinical trials.
Authors
- Karine Fauria (ORCID: https://orcid.org/0000-0003-1506-4405)
- Gonzalo Sánchez Benavides
- Luigi Lorenzini (ORCID: https://orcid.org/0000-0002-9756-881X)
- Carles Falcón (ORCID: https://orcid.org/0000-0001-5564-2025)
- Anna Brugulat‐Serrat (ORCID: https://orcid.org/0000-0001-8988-5658)
- José Luís Molinuevo (ORCID: https://orcid.org/0000-0003-0485-6001)
- Marc Suárez Calvet
- Silvia Ingala
- Raffaele Cacciaglia (ORCID: https://orcid.org/0000-0002-9216-949X)
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Juan Domingo Gispert (ORCID: https://orcid.org/0000-0002-6155-0642)
- Alle Meije Wink (ORCID: https://orcid.org/0000-0002-8197-0118)
- Karen A. Ritchie (ORCID: https://orcid.org/0000-0002-0688-8982)
- Gwendlyn Kollmorgen
- Kaj Blennow
- Carolina Minguillón (ORCID: https://orcid.org/0000-0002-2782-6908)
- Clara Quijano‐Rubio (ORCID: https://orcid.org/0000-0001-9050-3282)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0002-4671-6763)
- Marta Milà Alomà
Institutions
- Roche (Switzerland) (CH)
- University of Wisconsin–Madison (US)
- Universitat Pompeu Fabra (ES)
- Sahlgrenska University Hospital (SE)
- Roche Pharma AG (Germany) (DE)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Pasqual Maragall Foundation (ES)
- UK Dementia Research Institute (GB)
- Barcelonaβeta Brain Research Center (ES)
- Hospital Del Mar (ES)
- Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (ES)
- National Hospital for Neurology and Neurosurgery (GB)
- Amsterdam University Medical Centers (NL)
- Global Brain Health Institute (US)
- Northern California Institute for Research and Education (US)
- University College London (GB)
- Vrije Universiteit Amsterdam (NL)
- University of Gothenburg (SE)
- University of Edinburgh (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14415
- Citations
- 8
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 9.31
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Familjen Erling-Perssons Stiftelse
- Stiftelsen för Gamla Tjänarinnor
- EU Joint Programme – Neurodegenerative Disease Research
- Ministerio de Ciencia, Innovación y Universidades
- University College London
- European Commission
- Hjärnfonden
- Vetenskapsrådet
- UK Dementia Research Institute
- Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona
- National Institutes of Health
- HORIZON EUROPE Framework Programme
- Instituto de Salud Carlos III
- Agencia Estatal de Investigación