Pharmacological Evaluation of Tricholepis glaberrima for Antidiabetic potential in animal model

Tricholepis glaberrima commonly known as Potato weed widely used in traditional system of medicine for the treatment of diabetes mellitus In the present study, Methanol extract of Tricholepis glaberrima (METG) leaves were subjected to phytochemical investigation and evaluated for antidiabetic activity in STZ induced diabetic rats. METG (100, 200mg/kg) and Glibenclamide (5mg/kg) were administered orally in STZ (60mg/kg, i.p.) induced diabetic rats. In acute oral toxicity (OECD Guide line 423) study, administration of METG no mortality upto 1000mg/kg was observed. OGTT, fasting blood glucose level, body weight, plasma insulin, were evaluated in normal and diabetic rats. preliminary phytochemical investigation revealed the presence of alkaloids, flavonoids, glycosides, tannins as the major constituents in the methanol extract of Tricholepis glaberrima. These results suggest that METG (200mg/kg) showed antihyperglycemic activity in STZ induced diabetic rats.