Comparative Analysis of Tunicate vs. Plant-Based Cellulose in Chitosan Hydrogels for Bone Regeneration

A novel hydrogel scaffold for bone regeneration based on chitosan, selected for its biocompatibility, biodegradability, and antimicrobial properties, was covalently functionalized with a bioactive peptide from bone morphogenetic protein-2 (BMP-2) to guide osteoblast growth and proliferation. This study evaluates the impact of incorporating different concentrations (8, 16, or 24% <i>wt</i>/<i>wt</i>) of plant-based micro-fibrillated cellulose or tunicate nanocellulose to improve the mechanical and biological properties of peptide-grafted chitosan hydrogel matrices. While the mechanical properties of the matrices increase with increasing cellulose content, regardless of its source, the behavior of human osteoblasts used in biological tests discriminates between the two types of cellulose and shows better results (proliferation at 2 and 7 days, and mineralization) for the enrichment with tunicate cellulose.

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Publication Details

Journal
Gels
Published
2025-02-01
DOI
https://doi.org/10.3390/gels11020102
Citations
4
Primary Topic
Bone Tissue Engineering Materials
Type
article
Field-Weighted Citation Impact
2.70

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article

Comparative Analysis of Tunicate vs. Plant-Based Cellulose in Chitosan Hydrogels for Bone Regeneration

Elisabetta Schievano, Annj Zamuner, Monica Dettin, Gabriella D’Auria et al.
4 citations
Gels
Bone Tissue Engineering Materials
2.70
article

Comparative Analysis of Tunicate vs. Plant-Based Cellulose in Chitosan Hydrogels for Bone Regeneration

Elisabetta Schievano, Annj Zamuner, Monica Dettin, Gabriella D’Auria, Lorenzo Furlan, Teresa Russo, Vito Gallicchio, Paola Brun, Loriano Ballarin, Lucia Manni, Lucia Falcigno, Giacomo Sabbadin, Andrea Riccioni
article en
4 citations

Abstract

A novel hydrogel scaffold for bone regeneration based on chitosan, selected for its biocompatibility, biodegradability, and antimicrobial properties, was covalently functionalized with a bioactive peptide from bone morphogenetic protein-2 (BMP-2) to guide osteoblast growth and proliferation. This study evaluates the impact of incorporating different concentrations (8, 16, or 24% <i>wt</i>/<i>wt</i>) of plant-based micro-fibrillated cellulose or tunicate nanocellulose to improve the mechanical and biological properties of peptide-grafted chitosan hydrogel matrices. While the mechanical properties of the matrices increase with increasing cellulose content, regardless of its source, the behavior of human osteoblasts used in biological tests discriminates between the two types of cellulose and shows better results (proliferation at 2 and 7 days, and mineralization) for the enrichment with tunicate cellulose.

GelsVol. 11(2)
University of Padua (IT), National Research Council (IT), Institute of Polymers, Composites and Biomaterials (IT), University of Naples Federico II (IT)
Università degli Studi di Padova, Regione del Veneto
Reduced inequalities
Openalex Percentile: Top 12%
Bone Tissue Engineering Materials
2.70
DOIOpen Access PDFOpenAlex
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