Analysis of pH, electrolytes and non-invasive respiratory support in COPD with elevated CO2
The contributions of pH balance and electrolytes among patients with chronic obstructive pulmonary disease (COPD) experiencing hypercapnic exacerbations requiring non-invasive ventilation (NIV) are of interest. Hence, we used samples from 70 patients admitted in a tertiary care hospital from January to June 2023. The main variable analyzed was arterial blood gas data and serum electrolyte levels. A positive correlation between bicarbonate levels and PCO<sup>2</sup> was found, with p < 0.01 and r = 0.74, indicating metabolic compensation for respiratory acidosis. NIV was required in the majority of patients: in 64.3%, values were higher for both PCO<sup>2</sup> (52.3 ± 7.1 mmHg vs. 39.6 ± 4.3 mmHg) and bicarbonate levels (32.4 ± 4.8m Eq/L vs. 26.1 ± 3.1 m Eq/L; p < 0.01) in the NIV group. Thus, data highlights the role of monitoring PCO<sup>2</sup> and bicarbonate in guiding the use of NIV and in a more secondary role to hypercapnia disturbances in electrolytes.
Authors
- Yazan Khatib
- Mohammed Abdul Mateen (ORCID: https://orcid.org/0000-0002-1416-2727)
- N Aishwarya (ORCID: https://orcid.org/0009-0006-8118-1879)
- Rabia Azam (ORCID: https://orcid.org/0009-0003-9302-8319)
- Hamza A. Orfali (ORCID: https://orcid.org/0009-0000-1472-1819)
- Rida Minhaj
- M. Yousuff Hussaini
- Maanasa Kurapati
- Zehra Yousuf
- Mohamedelfatihmusaab Ibrahim Mohamed
Institutions
- Alfaisal University (SA)
- Deccan College of Medical Sciences (IN)
- Shadan Hospital and Institute of Medical Sciences (IN)
- Al-Neelain University (SD)
- Bolan University of Medical and Health Sciences (PK)
- National Ribat University (SD)
- Institute of Medical Sciences (IN)
Publication Details
- Journal
- Bioinformation
- Published
- 2024-11-30
- DOI
- https://doi.org/10.6026/9732063002001503
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00