Correlation between Melancholic Depression and Markers of Coagulopathy in Hemodialysis Patients

Background: Approximately 280 million individuals have depression worldwide. Melancholic depression has shown an increase after the COVID-19 pandemic, which is known to induce a pro-coagulant condition.Aim of the Work: We intend to examine the potential association between melancholic depression and coagulopathy in hemodialysis patients. Hemodialysis have high risk for depression.Methods: This research used a cross-sectional design and included a sample of forty-one patients aged between 18 and 69 years who were undergoing regular haemodialysis (HD) for a duration exceeding six months. The patient had an interview that included the Sydney Melancholia Scale. After obtaining written informed permission from all patients, CBC, D-dimer, Fibrinogen, Protein C, Protein S, and Factor VII were collected for each patient.Results: Elevated D-dimer levels were positively correlated with depression in patients with both melancholic and non-melancholic depression compared with patients without depression. Moreover, elevated D-dimer levels were positively correlated with the Sydney melancholia prototype index SMPI; that is, patients with melancholic depression have significantly higher D-dimer levels than patients with other types of depression and non-depressed patients. Patients with melancholic depression had a significantly lower mean total leukocytic count than those without depression did.Conclusion: Depression is a disabling illness that may include several types of presentations. The percentage of depression in our sample about 68.29%. There’s significant correlation that has been established in this research work between depression and the presence of coagulopathy markers. This could have a role in the future in prophylaxis and decreasing incidence of depression in high risk patients and also decreases thrombosis risk.