Central Compartment Atopic Disease: Clinical Characteristics and Cellular Endotypes in the Egyptian Population

Background: In the current study, we aim to investigate the clinical presentations and cellular endotypes of Central Compartment Atopic Disease in the Egyptian population and its percentage. Methods and Patients: A total of 101 patients diagnosed with CRSwNP at Ain Shams University Hospital were included in our study. Patients were categorized into two groups: those with CCAD (N=14) and those with other types of CRSwNP (N=87). Age, sex, smoking status, family history of allergies, allergic rhinitis were among the clinical data gathered. The intensity of the symptoms was evaluated using the Sinonasal Outcome Test score. The eosinophilic count in peripheral blood, total IgE levels, radiological scores, skin prick test results and endoscopic scores were all part of the diagnostic work-up. Cellular infiltration grading was done.Results: Comparing the 2 groups showed that the SNOT score was significantly lower in the CCAD group compared to the other CRSwNP group, p < .001. This suggests that patients with CCAD experience less severe symptoms. The CCAD group had significantly higher total IgE levels compared to the other CRSwNP group with p = .002. Additionally, the radiological and endoscopic scores were significantly lower in the CCAD group.Conclusion: This study provides a comprehensive analysis of clinical characteristics and the cellular endotypes of CCAD in an Egyptian population. The significant differences emphasize the need for targeted diagnostic tools and personalized treatment strategies. Future research should focus on elucidating the underlying mechanisms driving these differences to enhance the management of CCAD.