Metagenomic Sequencing Combined with Metabolomics to Explore Gut Microbiota and Metabolic Changes in Mice with Acute Myocardial Infarction and the Potential Mechanism of Allicin
Our study demonstrated that allicin alleviated myocardial injury and reduced inflammatory response by inhibiting the NF-κB-mediated NLRP3/Caspase-1/GSDMD pathway while remodeling microbiota disturbance, improving serum metabolic disorder, and enhancing the intestinal barrier. These research findings offer a novel perspective on the potential therapeutic value of allicin as an adjunctive dietary supplement to conventional treatments for AMI.
Authors
- Xianlun Li (ORCID: https://orcid.org/0000-0001-7553-6203)
- Yijie Gao (ORCID: https://orcid.org/0009-0005-9300-5445)
- Hongwei� Jiang (ORCID: https://orcid.org/0000-0003-3807-7989)
- Baofu Wang (ORCID: https://orcid.org/0000-0002-9913-5989)
- Fangyuan Luo (ORCID: https://orcid.org/0000-0003-3717-244X)
- Mengru Liu (ORCID: https://orcid.org/0000-0003-0856-7223)
- Gaofeng Qin
- Jiajie Yin
- Shichao Liang
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/dddt.s504884
- Citations
- 5
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.03