“Hypolipidemia-to Treat or Not”: Case Report of a Family with Hypolipidemia and Review of Literature

Background: Hypolipidemia denotes lower-than-normal levels of lipids in the blood, such as cholesterol and triglycerides. While elevated lipid levels are commonly linked to cardiovascular issues, very low levels can also pose health risks. Given the potential dangers associated with hypercholesterolemia for heart health, reduced lipid levels are often considered favorable or inconsequential from a clinical perspective. This report presents a case involving an asymptomatic 29-year-old male with unusually low cholesterol levels who underwent detailed evaluation along with his family members. Methods: PubMed/Medline/Cochrane reviews, National guideline clearing house and various others were used to search for literature and case reports on familial hypobetalipoproteinemia, heterozygous familial hypobetalipoproteinemia, abetalipoproteinemia, and hypolipidemia. Results: The analysis revealed this patient family to have a Class 1 Disorder due to lipoprotein assembly and secretion defect-2 Heterozygous Familial hypolipobetaproteinemia. Heterozygous familial hypobetalipoproteinemia is often asymptomatic and may be observed on routine testing. Conclusion: The patient is diagnosed with Heterogenous FHBL on clinical and laboratory basis needs to be followed up as hepatic steatosis can be a potential problem for patient. Confirmation of the diagnosis can be achieved with further genetic testing.