Giant Keratoacanthoma Centrifugum Marginatum: A Rare Case Report with Note on Literature Review

Introduction: Keratoacanthoma Centrifugum Marginatum (KCM) is a rare variant of keratoacanthoma that closely mimics squamous cell carcinoma (SCC), posing significant diagnostic challenges. Case Report: A 45-year-old male presented with a progressively enlarging hyperkeratotic lesion on the right cheek. Histopathological examination revealed pseudocarcinomatous hyperplasia with a central keratin plug, and MRI confirmed the lesion was confined to subcutaneous tissues without deeper invasion. Surgical excision was advised. Conclusion: This case highlights the importance of distinguishing KCM from SCC to prevent overtreatment. Surgical excision remains the preferred treatment, complemented by regular postoperative follow-ups for recurrence monitoring.