The association of lipids and novel non-statin lipid-lowering drug target with osteoporosis: evidence from genetic correlations and Mendelian randomization
MR analysis indicated causal associations between genetically predicted TGs and OP and BMD. Drug-target MR analysis showed that ANGPTL3 and APOC3 have the potential to serve as novel non-statin lipid-lowering drug targets to treat or prevent OP.
Authors
- Rongjie Lin (ORCID: https://orcid.org/0000-0001-7471-9083)
- Qingcong Zheng (ORCID: https://orcid.org/0009-0009-3978-7852)
- Du Wang (ORCID: https://orcid.org/0000-0001-6982-5842)
- Rongsheng Chen (ORCID: https://orcid.org/0000-0002-1208-9458)
- Weihong Xu
Institutions
- Fujian Medical University (CN)
- Peking University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Peking University People's Hospital (CN)
- Union Hospital (CN)
Publication Details
- Journal
- BMC Musculoskeletal Disorders
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1186/s12891-024-08160-z
- Primary Topic
- Lipid metabolism and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Fujian Province