CD155 promotes the progression of colorectal cancer by restraining CD8+ T cells via the PI3K/AKT/NF-κB pathway
This study revealed that CD155 can promote the progression of colorectal cancer by regulating the PI3K / AKT-NF-κB pathway to promote the depletion of CD8<sup>+</sup> T cells and reduce their migration to the tumor microenvironment. CD155 may become an important prognostic biomarker and an effective target for colorectal cancer immunotherapy.
Authors
- Yiquan Li (ORCID: https://orcid.org/0009-0007-0269-835X)
- Jiannan Ren (ORCID: https://orcid.org/0000-0003-1302-5007)
- Rongpu Liang (ORCID: https://orcid.org/0000-0002-5526-0753)
- Liting Liu (ORCID: https://orcid.org/0000-0002-5463-4821)
- Bo Wei (ORCID: https://orcid.org/0000-0002-1058-5888)
- Dongbing Ding (ORCID: https://orcid.org/0009-0005-2585-3784)
Institutions
- Sun Yat-sen University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1007/s00262-025-03947-y
- Citations
- 4
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- Natural Science Foundation of Guangdong Province
- Basic and Applied Basic Research Foundation of Guangdong Province