Serum neurofilament light chain but not serum glial fibrillary acidic protein is a marker of early Huntington’s disease
Our study indicates that sNfL can detect changes in very early and premanifest HD stages, whereas sGFAP showed differences in more advanced stages only.
Authors
- Atbin Djamshidian (ORCID: https://orcid.org/0000-0001-7174-6000)
- Arabella Buchmann (ORCID: https://orcid.org/0000-0002-7381-2427)
- Rina Demjaha (ORCID: https://orcid.org/0000-0001-9725-9809)
- Katarína Schwarzová (ORCID: https://orcid.org/0009-0006-0350-7861)
- Beatrice Heim (ORCID: https://orcid.org/0000-0002-6749-3044)
- Marina Peball (ORCID: https://orcid.org/0000-0002-0791-7300)
- Michael Khalil (ORCID: https://orcid.org/0000-0002-5350-3328)
- E. Mandler
- Klaus Seppi (ORCID: https://orcid.org/0000-0001-6503-1455)
- Cansu Tafrali (ORCID: https://orcid.org/0009-0003-2910-3791)
- Federico Carbone (ORCID: https://orcid.org/0000-0002-6909-0150)
Institutions
- Innsbruck Medical University (AT)
- Universität Innsbruck (AT)
- Medical University of Graz (AT)
- University of Applied Sciences Kufstein (AT)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1007/s00415-025-12901-y
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00