KMO-driven metabolic reconfiguration and its impact on immune cell infiltration in nasopharyngeal carcinoma: a new avenue for immunotherapy
The mitochondrial hub gene KMO plays a pivotal role in regulating mitochondrial metabolism and modulating the immune microenvironment in NPC. As a potential prognostic biomarker, KMO may offer valuable predictive insights, and targeting KMO could represent a promising therapeutic strategy for NPC, potentially enhancing the efficacy of immunotherapies.
Authors
- Yuan Zong (ORCID: https://orcid.org/0000-0003-0576-6614)
- Xingmei Sun
- Yi Yang (ORCID: https://orcid.org/0000-0002-9835-4098)
- Nijun Chen
- Yang Chen (ORCID: https://orcid.org/0000-0002-3575-3163)
- Xianfei Xie (ORCID: https://orcid.org/0000-0003-3234-2665)
- Ning Li (ORCID: https://orcid.org/0000-0002-1626-5519)
- Xiaoyu Zhao (ORCID: https://orcid.org/0000-0001-5095-7212)
- Liting Jiang (ORCID: https://orcid.org/0000-0002-2342-2017)
- Jiawen Zhao (ORCID: https://orcid.org/0000-0003-2917-8630)
- Lei Li (ORCID: https://orcid.org/0000-0002-3858-3710)
Institutions
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1007/s00262-024-03928-7
- Citations
- 6
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.78