Effect of RAS mutations and related immune characteristics on the prognosis of patients with MSI-H/dMMR colorectal cancer
RAS mutations in patients with MSI-H/dMMR CRC may reduce the infiltration of CD11c<sup>+</sup> dendritic cells, CD4<sup>+</sup> T cells, and CD8<sup>+</sup> T cells, and increase the infiltration of Foxp3<sup>+</sup> Treg cells to affect the tumor microenvironment of patients. RAS gene status, CD11c + cells infiltration, and CA19-9 level were potential prognostic factors for MSI-H/dMMR CRC.
Authors
- Tiantian Zhao (ORCID: https://orcid.org/0000-0002-7655-3627)
- Yawen Gao (ORCID: https://orcid.org/0000-0002-9499-3765)
- Zengyi Zhao
- Yupeng Jiang (ORCID: https://orcid.org/0000-0001-8971-2079)
- Yuyao Liu (ORCID: https://orcid.org/0009-0007-5443-9480)
- Hong Huang
Institutions
- Central South University (CN)
- Guilin Medical University (CN)
- Changsha Central Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- University of South China (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1007/s00262-024-03926-9
- Citations
- 5
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 7.36
Funders
- Hunan Provincial Science and Technology Department
- Natural Science Foundation of Hainan Province