Does Time to Retreatment Matter? A Normal Tissue Complication Probability Model to Predict Radionecrosis After Repeat Stereotactic Radiosurgery for Recurrent Brain Metastases Incorporating Time-dependent Discounted Dose
The model-fitted parameters predicted that recurrent BMs would have a lower threshold dose tolerance and a more gradual dose response to the second SRS than nonrecurrent BMs. This gradual dose-response becomes even more apparent when considering the time-dependent discounted first SRS as a cumulative second SRS. Tailoring SRS retreatment protocols based on NTCP modeling can potentially enhance therapeutic efficacy.
Authors
- Issam El Naqa (ORCID: https://orcid.org/0000-0001-6023-1132)
- Penny K. Sneed (ORCID: https://orcid.org/0000-0003-0487-4250)
- M. L. SHARMA (ORCID: https://orcid.org/0000-0003-0021-1265)
Institutions
- University of California, San Francisco (US)
- Moffitt Cancer Center (US)
Publication Details
- Journal
- International Journal of Radiation Oncology*Biology*Physics
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1016/j.ijrobp.2025.01.017
- Citations
- 4
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- University of California, San Francisco