Evaluation of ulcer healing activity of Mahonia napaulensis in Swiss albino mice

Introduction:The indigenous population of Nagaland has traditionally utilized the bark of Mahonia napaulensis as a remedy for gastrointestinal ailments; however, its therapeutic effectiveness has not been scientifically verified.The objective of the current investigation is to assess the efficacy of the methanolic bark extract of M. napaulensis in promoting the healing of peptic ulcers.Methods: The study involved the induction of ulcers in Swiss albino mice via the oral administration of a single dose of 80% ethanol (1 ml/100g body weight).The effect of the methanolic bark extract of the plant on ethanol-induced peptic ulcer was studied using repeated dosing of 200 mg/kg body weight for ten and fourteen days, respectively.The standard drug utilized in the study was Ranitidine (30 mg/kg body weight).The assessment of ulcer healing activity was conducted through the evaluation of various parameters, including the ulcer index, healing percentage, gross macroscopic lesions, as well as histopathological and ultrastructural observations.The concentrations of malondialdehyde (MDA), glutathione (GSH), protein, and sialic acid were quantified. Results:The results indicate that the oral consumption of methanolic bark extract of M. napaulensis has pro-healing efficacy on ulcerated mice.Thus, this justifies the use of the plant as a healing agent among the rural population. Conclusion:The results indicate that the oral consumption of methanolic bark extract of M. napaulensis has pro-healing efficacy on ulcerated mice.Thus, this justifies the use of the plant as a healing agent among the rural population.