Genetic and environmental contribution to phenotypic resemblance between Iranian couples: Tehran Cardiometabolic and Genetic Study (TCGS)
Our findings support the AM hypothesis for height with a significant spousal correlation and show that selecting the spouse's height is genetically determined. Besides, we provide data showing that AM is predicted to result in a10 % increase in the heritability of height, which is related to the assortative nature of alleles in the population and not to the segregation of genetic variations. Finally, as one of the evolutionary consequences of AM, long-term spousal resemblance provided an increasing trend for correlation between spouses in terms of their lipid serum level and obesity-related traits.
Authors
- Maryam Zarkesh (ORCID: https://orcid.org/0000-0002-8519-4865)
- Amir Hossein Saeidian (ORCID: https://orcid.org/0000-0003-3512-0654)
- Kamran Guity (ORCID: https://orcid.org/0000-0002-8379-9668)
- Michael March (ORCID: https://orcid.org/0000-0001-9173-6862)
- Mahdi Akbarzadeh (ORCID: https://orcid.org/0000-0002-8048-744X)
- Albert Tenesa (ORCID: https://orcid.org/0000-0003-4884-4475)
- Mahmoud Amiri Roudbar (ORCID: https://orcid.org/0000-0002-2023-9292)
- Parisa Riahi
- Mehdi Hedayati (ORCID: https://orcid.org/0000-0001-5816-775X)
- Asieh Sadat Zahedi
- Maryam S. Daneshpour (ORCID: https://orcid.org/0000-0003-1525-8672)
- Carolyn T. Hogan
- Farideh Neshati
- Fereidoun Azizi (ORCID: https://orcid.org/0000-0002-7515-5651)
- Hákon Hákonarson
Institutions
- Children's Hospital of Philadelphia (US)
- Roslin Institute (GB)
- University of Iceland (IS)
- Baylor College of Medicine (US)
- Western General Hospital (GB)
- Research Institute for Endocrine Sciences (IR)
- Temple University Hospital (US)
- Agricultural Research & Education Organization (IR)
- Shahid Beheshti University of Medical Sciences (IR)
- University of Pennsylvania (US)
- University of Edinburgh (GB)
Publication Details
- Journal
- Heliyon
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1016/j.heliyon.2025.e42401
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Amgen