The role of cytokines as predictors for NAFLD-related diseases: A bidirectional Mendelian randomization study
Our MR analysis identifies specific cytokines as genetic predictors for NAFLD and NASH. IL-2 and TNF-β increase NAFLD risk, IL-16 appears protective, and β-NGF and SCGFβ are associated with greater NASH risk. These insights are crucial for understanding the etiology and treatment of NAFLD-related diseases.
Authors
- Weiping Wang (ORCID: https://orcid.org/0000-0002-6619-1191)
- Yin Xia (ORCID: https://orcid.org/0000-0003-0315-7532)
- Qian Li (ORCID: https://orcid.org/0000-0002-6427-3783)
- Yijia He (ORCID: https://orcid.org/0009-0000-5621-7063)
- Ziyi Zhong
- Miaomin Ye
Institutions
- Nanjing Medical University (CN)
Publication Details
- Journal
- Clinics and Research in Hepatology and Gastroenterology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1016/j.clinre.2025.102545
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.42