Tape-strip profiling identifies unique immune and lipid dysregulation in patients with seborrheic dermatitis
These data deepen our understanding of SD suggesting that it has robust Th17/Th22, some Th1 skewing, and minimal Th2 activation, and associated skin barrier alterations. This provides rationale for novel immunomodulatory treatment approaches for SD patients targeting IL23/Th17 and/or Th22 pathways.
Authors
- Jesús Gay-Mimbrera (ORCID: https://orcid.org/0000-0001-7223-1922)
- Meredith Manson (ORCID: https://orcid.org/0009-0008-6404-1588)
- Avner Shemer (ORCID: https://orcid.org/0000-0001-5084-5819)
- Madeline Kim (ORCID: https://orcid.org/0000-0002-8108-3631)
- Emma Guttman‐Yassky (ORCID: https://orcid.org/0000-0002-9363-324X)
- Panipak Temboonnark
- Patrick Burnett (ORCID: https://orcid.org/0000-0002-7123-9161)
- Yeriel Estrada (ORCID: https://orcid.org/0000-0002-5172-6747)
- Benjamin Ungar (ORCID: https://orcid.org/0000-0003-0882-8163)
- Pedro Jesús Gómez‐Arias (ORCID: https://orcid.org/0000-0003-0962-6950)
- Juan Ruano (ORCID: https://orcid.org/0000-0002-0286-4107)
- Digpal Singh Gour (ORCID: https://orcid.org/0009-0002-6908-2211)
- Diane T. Hanna (ORCID: https://orcid.org/0000-0003-1162-9341)
- Joel Corrêa da Rosa (ORCID: https://orcid.org/0000-0003-4221-1976)
- Ragasruti Metukuru
Institutions
- Sheba Medical Center (IL)
- Atara Biotherapeutics (United States) (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Journal of the American Academy of Dermatology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1016/j.jaad.2025.01.082
- Citations
- 12
- Primary Topic
- Nail Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 16.25