Multiomic analysis uncovers a continuous spectrum of differentiation and Wnt-MDK-driven immune evasion in hepatoblastoma
Despite hepatoblastoma being the most common pediatric liver cancer, there has been a critical knowledge gap in understanding how the tumor microenvironment and immune landscape contribute to disease progression. Our novel findings, revealing a continuous spectrum of tumor differentiation states and Wnt-MDK-driven immune evasion, are significant for pediatric oncology clinicians and researchers, improving our functional understanding of the immune environment of hepatoblastoma. The identification of midkine as a tumor-specific immunomodulator suggests a potential for developing new targeted therapies, though further mechanistic and practical validation would be needed to realize clinical translation of these findings.
Authors
- Andreas Pascher (ORCID: https://orcid.org/0000-0002-0801-1949)
- Noelia A-González (ORCID: https://orcid.org/0000-0003-0533-5216)
- Mathis Richter (ORCID: https://orcid.org/0000-0002-3110-6137)
- Beate Winkler (ORCID: https://orcid.org/0000-0002-4050-9819)
- Wolfgang Hartmann (ORCID: https://orcid.org/0000-0002-7609-5021)
- Rajanya Roy
- Thomas A. Kluiver (ORCID: https://orcid.org/0000-0003-2224-480X)
- Thomas Albert (ORCID: https://orcid.org/0000-0002-2488-0706)
- Claudia Rössig (ORCID: https://orcid.org/0000-0002-8672-5285)
- Eva Jüttner
- Oliver Soehnlein (ORCID: https://orcid.org/0000-0002-7854-0694)
- Nicole Riedel (ORCID: https://orcid.org/0009-0002-4256-0746)
- Urs Mücke (ORCID: https://orcid.org/0000-0002-0240-248X)
- Kornelius Kerl (ORCID: https://orcid.org/0000-0002-5676-8102)
- Simon Vieth (ORCID: https://orcid.org/0000-0002-2765-1589)
- Jérôme Schlué
- Sarah Sandmann (ORCID: https://orcid.org/0000-0002-5011-0641)
- Irene Aranda-Pardos (ORCID: https://orcid.org/0000-0002-8904-1532)
- Flavia W. de Faria (ORCID: https://orcid.org/0000-0003-0162-6331)
- Marc Hotfilder (ORCID: https://orcid.org/0000-0001-9964-1761)
- Volker Müller (ORCID: https://orcid.org/0000-0001-7955-5508)
- Clara Inserte (ORCID: https://orcid.org/0000-0001-7371-8839)
- Shariyah Rahman
- Weng Chuan Peng (ORCID: https://orcid.org/0000-0001-5467-5458)
- Omid Madadi‐Sanjani (ORCID: https://orcid.org/0000-0002-7239-8973)
- Christian Vokuhl (ORCID: https://orcid.org/0000-0002-4138-4536)
- Daniel Münter (ORCID: https://orcid.org/0000-0001-8823-0238)
- Carolin Walter (ORCID: https://orcid.org/0000-0002-5155-7728)
- Irene Schmid (ORCID: https://orcid.org/0000-0002-5105-3597)
- Karsten Wiebe
- Enya Paga
Institutions
- Universität Hamburg (DE)
- University of Münster (DE)
- University Hospital Bonn (DE)
- Medizinische Hochschule Hannover (DE)
- University Hospital Münster (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- University Hospital Schleswig-Holstein (DE)
- Princess Máxima Center (NL)
- Hanover College (US)
- Ludwig-Maximilians-Universität München (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Journal of Hepatology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1016/j.jhep.2025.01.031
- Citations
- 14
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 11.16
Funders
- Deutsche Forschungsgemeinschaft
- Fondation Leducq
- Novo Nordisk