A rapid genome-proteome approach to identify rate-limiting steps in the butyrate production pathway in probiotic Clostridium butyricum, CBM588
Our findings pave the way for over-expressing these genes chromosomally to generate a recombinant probiotic with improved butyrate production and potentially enhanced gut health properties.
Authors
- Bunmi B. Omorotionmwan (ORCID: https://orcid.org/0000-0002-0798-0588)
- Tom S. Bailey (ORCID: https://orcid.org/0000-0002-3413-327X)
- Liam Wood (ORCID: https://orcid.org/0000-0002-4176-1071)
- David Tooth
- Ruth Griffin (ORCID: https://orcid.org/0000-0002-0269-059X)
- Adam Dowle (ORCID: https://orcid.org/0000-0002-6501-5444)
- Adam Blanchard (ORCID: https://orcid.org/0000-0001-6991-7210)
Institutions
- University of Nottingham (GB)
- Maastricht University (NL)
- Nottingham College (GB)
- Nottingham Biomedical Research Centre (GB)
- University of York (GB)
- Nottingham Trent University (GB)
Publication Details
- Journal
- Anaerobe
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1016/j.anaerobe.2025.102940
- Citations
- 4
- Primary Topic
- Microbial Metabolic Engineering and Bioproduction
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Engineering and Physical Sciences Research Council
- Biotechnology and Biological Sciences Research Council