Evaluation of the need for dosing adaptations in obese patients for surgical antibiotic prophylaxis: a model-based analysis of cefazolin pharmacokinetics
This model-based analysis, using fT<sub>>MIC</sub> = 100% as a target, showed that cefazolin dosing adaptations are not required for surgical prophylaxis in obese patients.
Authors
- Wilhelm Huisinga (ORCID: https://orcid.org/0000-0002-5249-3914)
- Davide Bindellini (ORCID: https://orcid.org/0009-0000-0758-5951)
- Christoph Dorn (ORCID: https://orcid.org/0000-0002-2560-9598)
- Hermann Wrigge (ORCID: https://orcid.org/0000-0002-9035-6822)
- Markus Zeitlinger (ORCID: https://orcid.org/0000-0002-1873-3953)
- Robin Michelet (ORCID: https://orcid.org/0000-0002-5485-607X)
- David Petroff (ORCID: https://orcid.org/0000-0002-6916-1465)
- David Busse (ORCID: https://orcid.org/0000-0003-2738-7797)
- Linda B. S. Aulin (ORCID: https://orcid.org/0000-0003-4840-5704)
- Charlotte Kloft (ORCID: https://orcid.org/0000-0001-9344-8514)
- Philipp Simon (ORCID: https://orcid.org/0000-0003-2696-3254)
Institutions
- Boehringer Ingelheim (Germany) (DE)
- University of Potsdam (DE)
- IFB Adiposity Diseases (DE)
- BG Klinikum Bergmannstrost Halle (DE)
- University of Regensburg (DE)
- Martin Luther University Halle-Wittenberg (DE)
- Freie Universität Berlin (DE)
- Medical University of Vienna (AT)
- Leipzig University (DE)
Publication Details
- Journal
- British Journal of Anaesthesia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1016/j.bja.2024.11.044
- Citations
- 4
- Primary Topic
- Surgical site infection prevention
- Type
- article
- Field-Weighted Citation Impact
- 8.03
Funders
- Clinical Trial Center, China Medical University Hospital
- Bundesministerium für Bildung und Forschung