Cabergoline-induced NDFIP1 upregulation in pituitary neuroendocrine tumor cells activates mTOR signaling and contributes to cabergoline resistance
CAB treatment induces the upregulation of NDFIP1 in PitNET cells, which correlates with tumor size and contributes to reduced CAB sensitivity, potentially through activation of the mTOR pathway. NDFIP1 as a potential therapeutic target for overcoming DA resistance in PitNET patients.
Authors
- Weifeng Zhang (ORCID: https://orcid.org/0000-0002-8926-1842)
- Weiting Gu
- Zhe Wu (ORCID: https://orcid.org/0000-0002-1611-8228)
- Yu Cai (ORCID: https://orcid.org/0000-0002-1519-910X)
Institutions
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
Publication Details
- Journal
- Journal of Neuro-Oncology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1007/s11060-025-04949-7
- Citations
- 1
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality