Epigene functional diversity: isoform usage, disordered domain content, and variable binding partners
Here we identify significant differences in isoform usage, disordered domain content, and variable binding partners between human epigenes and non-epigenes using various functional genomics datasets from Ensembl, ENCODE, GTEx, HPO, LINCS L1000, and BrainSpan. Our results contribute new knowledge to the growing field focused on developing targeted therapies for diseases caused by epigene mutations, such as chromatinopathies and cancers.
Authors
- Isabelle S. Liu
- Leroy Bondhus (ORCID: https://orcid.org/0000-0003-3398-5347)
- Aileen A. Nava (ORCID: https://orcid.org/0000-0002-2053-6713)
- Valerie A. Arboleda (ORCID: https://orcid.org/0000-0002-9687-9122)
Institutions
- University of California, Los Angeles (US)
- UCLA Health (US)
- Université Bourgogne Franche-Comté (FR)
- UCLA Jonsson Comprehensive Cancer Center
Publication Details
- Journal
- Epigenetics & Chromatin
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1186/s13072-025-00571-z
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Heart, Lung, and Blood Institute
- Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles