Preoperative stereotactic radiotherapy to prevent pancreatic fistula in high-risk patients undergoing pancreatoduodenectomy (FIBROPANC): prospective multicentre phase II single-arm trial
Preoperative stereotactic body radiotherapy is safe in high-risk patients undergoing pancreatoduodenectomy and increases parenchymal firmness and fibrosis, but fails to show evidence of efficacy.
Authors
- Roeland F. de Wilde (ORCID: https://orcid.org/0009-0003-0444-8697)
- Casper H.J. van Eijck (ORCID: https://orcid.org/0000-0002-9511-2157)
- Marc G. Besselink (ORCID: https://orcid.org/0000-0003-2650-9350)
- Martijn Intven (ORCID: https://orcid.org/0000-0002-5068-5517)
- Jaap Stoker (ORCID: https://orcid.org/0000-0002-9822-3784)
- Bas Groot Koerkamp (ORCID: https://orcid.org/0000-0003-1917-6973)
- Geertjan van Tienhoven (ORCID: https://orcid.org/0000-0002-2516-2263)
- Olivier R. Busch (ORCID: https://orcid.org/0000-0001-9605-6831)
- Lydi M.J.W. van Driel (ORCID: https://orcid.org/0000-0003-0616-7349)
- Joanne Verheij (ORCID: https://orcid.org/0000-0003-1283-630X)
- T. Hendriks (ORCID: https://orcid.org/0009-0007-7418-3056)
- Arantza Fariña Sarasqueta (ORCID: https://orcid.org/0000-0002-4307-1568)
- Leonoor V. Wismans (ORCID: https://orcid.org/0000-0002-7009-7034)
- J. Annelie Suurmeijer (ORCID: https://orcid.org/0000-0003-2972-5622)
- A. Bruynzeel (ORCID: https://orcid.org/0000-0002-7542-8920)
- Daan J. Lips (ORCID: https://orcid.org/0000-0001-7515-9276)
- Roel Haen
- Erwin van der Harst (ORCID: https://orcid.org/0000-0002-1317-5614)
- Joost J. Nuyttens (ORCID: https://orcid.org/0009-0002-5021-1597)
- Michail Doukas (ORCID: https://orcid.org/0000-0002-8611-840X)
- Onno J de Boer
Institutions
- Radboud University Nijmegen (NL)
- Leiden University Medical Center (NL)
- Catharina Ziekenhuis (NL)
- Cancer Institute (WIA) (IN)
- Medisch Spectrum Twente (NL)
- Erasmus MC (NL)
- University Medical Center (US)
- University Medical Center Utrecht (NL)
- Dutch Institute for Clinical Auditing (NL)
- Maasstad Ziekenhuis (NL)
- Erasmus MC Cancer Institute (NL)
- Amsterdam University Medical Centers (NL)
- Cancer Center Amsterdam (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- British journal of surgery
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1093/bjs/znae327
- Citations
- 4
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 4.18