Neuroprotective role of Da Qin Jiu decoction in ischemic stroke: Mitochondrial rescue through PI3K/Akt-mediated UPRmt activation
DQJD exerts neuroprotective effects in IS by restoring mitochondrial function through UPR<sup>mt</sup> activation via the PI3K/Akt pathway. These findings support further exploration of DQJD as a therapeutic option for IS.
Authors
- Jing Zhao (ORCID: https://orcid.org/0000-0001-6424-3085)
- Dou Hong (ORCID: https://orcid.org/0000-0003-4646-3994)
- Xin Xiong (ORCID: https://orcid.org/0000-0003-2175-0970)
- Jing Luo (ORCID: https://orcid.org/0000-0003-3022-9984)
- Jiashu Shen (ORCID: https://orcid.org/0000-0003-0176-0274)
- Ning Jiang (ORCID: https://orcid.org/0000-0001-5418-0914)
- Wenlu Li (ORCID: https://orcid.org/0000-0001-6507-392X)
- Jialei Chen (ORCID: https://orcid.org/0000-0001-6029-765X)
- Jingxian Wu
- Yaling Zheng
Institutions
- University of Oxford (GB)
- China International Science and Technology Cooperation (CN)
- Massachusetts General Hospital (US)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Oxford BioMedica (United Kingdom) (GB)
- Science Oxford (GB)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1016/j.jep.2025.119433
- Citations
- 3
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 7.14
Funders
- China Postdoctoral Science Foundation