Frequency and Early Predictors of Cognitive Deterioration in Amyotrophic Lateral Sclerosis: A Longitudinal Population‐Based Study
Approximately 30% of ALS patients experienced cognitive/behavioral decline within the first year after diagnosis. FAS and ECAS verbal fluency were predictive of cognitive phenoconversion. Our findings highlight the importance of early detection of at-risk individuals and the need for longitudinal cognitive assessments to monitor disease progression. ANN NEUROL 2025;97:1122-1133.
Authors
- Marco Pagani (ORCID: https://orcid.org/0000-0001-8125-1925)
- Antonio Canosa (ORCID: https://orcid.org/0000-0001-5876-4079)
- Gabriele Mora (ORCID: https://orcid.org/0000-0002-8388-2373)
- Enrico Matteoni (ORCID: https://orcid.org/0009-0008-2963-8821)
- Andrea Calvo (ORCID: https://orcid.org/0000-0002-5122-7243)
- Umberto Manera (ORCID: https://orcid.org/0000-0002-9995-8133)
- Barbara Iazzolino (ORCID: https://orcid.org/0000-0001-5748-9175)
- Rosario Vasta (ORCID: https://orcid.org/0000-0002-0393-4736)
- Francesca Palumbo (ORCID: https://orcid.org/0000-0002-7070-2409)
- Cristina Moglia (ORCID: https://orcid.org/0000-0001-7377-7222)
- Adriano Chiò (ORCID: https://orcid.org/0000-0001-9579-5341)
- Maura Brunetti
- Maurizio Grassano
- Sara Cabras
Institutions
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Equilibrium Research (GB)
- National Research Council (IT)
- Institute of Cognitive Sciences and Technologies (IT)
- University of Turin (IT)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/ana.27194
- Citations
- 1
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- European Commission
- Ministero della Salute
- Ministero dell’Istruzione, dell’Università e della Ricerca
- FP7 Health
- HORIZON EUROPE Health