Accelerated Cellular Senescence in Progressive Multiple Sclerosis: A Histopathological Study
Our data indicates that CS primarily affects actively demyelinating gray and WMLs. A higher senescent cell load in P-MS is associated with faster disability progression and death. ANN NEUROL 2025;97:1074-1087.
Authors
- Dimitrios Papadopoulos (ORCID: https://orcid.org/0000-0003-1806-7740)
- Vassilis G. Gorgoulis (ORCID: https://orcid.org/0000-0001-9001-4112)
- Richard Nicholas (ORCID: https://orcid.org/0000-0003-0414-1225)
- Sara Bandiera (ORCID: https://orcid.org/0000-0002-1203-8554)
- Lesley Probert (ORCID: https://orcid.org/0000-0002-5931-2880)
- Richard Reynolds (ORCID: https://orcid.org/0000-0003-4622-4694)
- Roberta Magliozzi (ORCID: https://orcid.org/0000-0001-8284-7763)
- Elena Barusolo
- Ilaria Cimignolo
Institutions
- University of Verona (IT)
- University of Dundee (GB)
- National and Kapodistrian University of Athens (GR)
- European University Cyprus (CY)
- Manchester Academic Health Science Centre (GB)
- Ninewells Hospital (GB)
- University of Manchester (GB)
- Pasteur Hellenic Institute (GR)
- Imperial College London (GB)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/ana.27195
- Citations
- 7
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 8.15
Funders
- Multiple Sclerosis Society
- Imperial College London