How to improve the quality of euglycemic glucose clamp tests in long-acting insulin studies
CVBG could be used as a standard for evaluating the quality of long-acting insulin euglycemic glucose clamp test, and the test quality was superior with a CVBG ≤ 3.5%. A C-peptide reduction ratio ≥ 50% indicated sufficient endogenous insulin inhibition; however, when the glucose fluctuation is small (CVBG is maintained at a low level) during the clamp test, even if the clamp test quality is slightly different, it is not sufficient to interfere with endogenous insulin secretion.
Authors
- Fu Kuang
- Yang Liu (ORCID: https://orcid.org/0000-0003-3175-8490)
- Li Li (ORCID: https://orcid.org/0000-0002-3203-901X)
- Yao Huang (ORCID: https://orcid.org/0000-0003-2278-2253)
- Xian Yu (ORCID: https://orcid.org/0000-0001-5009-2044)
- Yang Yi (ORCID: https://orcid.org/0000-0003-0716-6655)
- XueYing Zhu
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Trials
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1186/s13063-025-08749-2
- Citations
- 2
- Primary Topic
- Diabetes Management and Research
- Type
- article
- Field-Weighted Citation Impact
- 2.59
Funders
- Chongqing Medical University
- Natural Science Foundation of Chongqing
- Centre Scientifique et Technique du Bâtiment