ccfDNA analysis for the classification of adrenocortical adenomas
Total ccfDNA concentrations are higher in patients with CPA-CS. Despite the presence of somatic variants in half of tumor samples, we did not detect any at ccfDNA level. Therefore, this approach appears ineffective for pre-operative detection of genetic alterations.
Authors
- Alessandro Prete (ORCID: https://orcid.org/0000-0003-3633-6916)
- Miriam Asia
- Cristina L. Ronchi (ORCID: https://orcid.org/0000-0001-5020-2071)
- Kassiani Skordilis
- Yasir Elhassan (ORCID: https://orcid.org/0000-0002-2735-6053)
- David S. Tourigny (ORCID: https://orcid.org/0000-0002-3987-8078)
- Ana Crastin (ORCID: https://orcid.org/0009-0009-0450-6969)
- Silke Appenzeller (ORCID: https://orcid.org/0000-0002-5472-8692)
- Gabrielle Smith
- Juliane Lippert
- Oskar Podstawka
- Mengjie Xu
Institutions
- Hubei University of Medicine (CN)
- University Hospitals Birmingham NHS Foundation Trust (GB)
- University of Würzburg (DE)
- Queen Elizabeth Hospital Birmingham (GB)
- Comprehensive Cancer Center Mainfranken (DE)
- Taihe Hospital (CN)
- NIHR Birmingham Biomedical Research Centre (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- Journal of Endocrinological Investigation
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1007/s40618-025-02540-5
- Citations
- 1
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 1.29
Funders
- Queen Elizabeth Hospital Birmingham Charity
- National Institute for Health and Care Research
- Deutsche Krebshilfe
- Medical Research Council
- Birmingham Biomedical Research Centre