Gingivitis and periodontitis among Indian patients diagnosed using trefoil factor 3

Recently there has been an increased interest on the identifying and preventing the disease with profuse biomarkers. There are very few studies done in understanding the relationship of TFF3 levels in the diseased condition. Therefore, it is of interest to determine effect of non-surgical periodontal therapy on trefoil factor levels in patients with gingivitis and periodontitis. Study sample consisting of 40 subjects of which 20 with gingivitis and 20 with moderate chronic periodontitis were included. The clinical parameters assessed were gingival index, Plaque index, and Probing Depth and Clinical attachment levels. Enzyme linked immunosorbent assay was used to evaluate Serum Trefoil factor 3 (TFF3). Intra group comparisons in gingivitis and periodontitis group have shown that all clinical and biochemical parameters have significantly reduced from base line to 3 months. Increased serum TFF3 concentrations were observed after non-surgical periodontal therapy in both gingivitis and chronic periodontitis group (p<0.001). In conclusion clinical and biochemical analysis of serum TFF3 revealed its influence on periodontal disease activity. Elevated serum Trefoil factor 3 levels showed a strong association with decrease in clinical parameters taken after the therapy.