MORTALITY OUTCOMES ASSOCIATED WITH INVASIVE ASPERGILLOSIS

Prognostic variables for invasive aspergillosis (IA) are poorly recognised, despite the disease's high mortality rate. The majority of studies on clinical implications of Aspergillus species infections have focused on patients with opportunistic infection that primarily affects cancer patients and immunocompromised individuals who have prolonged neutropenia. This study was carried out prospectively in a tertiary care hospital in Navi Mumbai, India, between January 2014 and December 2015. Standard microbiological protocols were followed in the collection and processing of samples from a total of 1785 patients. Out of the 251 patients that tested positive for Aspergillus, 8 individuals (3.19%) died as a result of their infections; males were 5 (62.50%), and females were 3 (37.5%). Maximum age group for those over 50, or 5 (62.5%), is followed by those between the ages of 31 and 40, or 1 (12.5%), and 41 and 50, or 2 (25%). Five (62.5%) and three (37.5%) deaths were attributable to Aspergillus fumigatus and Aspergillus niger, respectively.The highest number of causes of mortality in cases of Aspergillosis was found to be Allergic Broncopulmonary Aspergillosis (ABPA), which accounted for 2 cases. This was followed by Chronic Pulmonary Aspergillosis, Invasive Aspergillosis in Solid Organ Transplant, HIV, Tuberculosis, Diabetes, and Lung Cancer, which each accounted for 1 case. The study assessed the variations in therapy, comorbidities, and demographics between the in-hospital mortality and survival groups. Additionally, multivariate analysis was done to find mortality risk factors. The current study displays the mortality trend for patients with IA during a two-year span. Acute renal failure, bone marrow transplantation, intubation, advanced age, male gender, and patients were on steroid use was identified as death risk factors.