Delta-opioid receptor signaling alleviates neuropathology and cognitive impairment in the mouse model of Alzheimer’s disease by regulating microglia homeostasis and inhibiting HMGB1 pathway
These novel findings uncover previously unappreciated roles of DOR in neuroprotection against AD injury via modulating microglia-related inflammatory responses.
Authors
- Yuan Xu (ORCID: https://orcid.org/0000-0003-1093-9428)
- Ying Xia (ORCID: https://orcid.org/0000-0002-0126-6594)
- Feng Zhi (ORCID: https://orcid.org/0000-0002-3414-0162)
- Ronghua Chen (ORCID: https://orcid.org/0000-0001-6863-530X)
- Ya Peng (ORCID: https://orcid.org/0000-0002-2761-4374)
- Nan Shao (ORCID: https://orcid.org/0000-0001-5523-7142)
- Jiahui Li (ORCID: https://orcid.org/0000-0003-4817-220X)
- Yilin Yang (ORCID: https://orcid.org/0009-0005-8883-4361)
Institutions
- Fudan University (CN)
- Soochow University (CN)
- The First People's Hospital of Changzhou (CN)
- Shanghai Research Center for Acupuncture and Meridians (CN)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1186/s13195-025-01682-1
- Citations
- 4
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.37
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality