Period3 modulates the NAD+-SIRT3 axis to alleviate depression-like behaviour by enhancing NAMPT activity in mice
These findings uncover a novel mechanism by which PER3 ameliorates depressive behaviors through the regulation of NAMPT-controlled NAD<sup>+</sup> levels and mitochondrial function, underscoring the critical role of PER3 in depression-related pathophysiology.
Authors
- Zezhi Li (ORCID: https://orcid.org/0000-0003-0241-1500)
- Ruonan Shu
- Daniel C. Anthony (ORCID: https://orcid.org/0000-0003-1380-6655)
- Xiaoxian Xie (ORCID: https://orcid.org/0000-0002-7079-1245)
- Lei Sun (ORCID: https://orcid.org/0000-0002-8310-1880)
- Liangliang Wang (ORCID: https://orcid.org/0000-0002-8350-0312)
- Haoshen Xu
- Mengya Zhang (ORCID: https://orcid.org/0000-0002-1001-0427)
- Jiafeng Zhou (ORCID: https://orcid.org/0009-0005-5056-3762)
- Hongzhao Fan
- Shulin Du
Institutions
- South China Agricultural University (CN)
- Mansfield University (US)
- Shanghai Mental Health Center (CN)
- Lishui University (CN)
- University of Oxford (GB)
- Zhejiang University of Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1016/j.jare.2025.01.043
- Citations
- 6
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 7.34
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Zhejiang University
- Shanghai Jiao Tong University
- Zhejiang University of Technology