Longitudinal associations between late-life depression, cerebrovascular disease and cognition
Our findings suggest that depression in later life may not precede cognitive decline. Instead, depressive symptoms and cognitive decline, particularly in attention and executive function, may evolve in tandem over time. This reinforces the importance of early identification and treatment of depression in older adults to potentially mitigate cognitive deterioration.
Authors
- Louise R. Mewton (ORCID: https://orcid.org/0000-0002-7812-296X)
- Simone Reppermund (ORCID: https://orcid.org/0000-0003-4785-0224)
- Henry Brodaty (ORCID: https://orcid.org/0000-0001-9487-6617)
- Katya T. Numbers (ORCID: https://orcid.org/0000-0002-7009-2401)
- Perminder Singh Sachdev (ORCID: https://orcid.org/0000-0002-9595-3220)
- Jiyang Jiang (ORCID: https://orcid.org/0000-0002-2147-6302)
- Ben C. P. Lam (ORCID: https://orcid.org/0000-0002-0879-5990)
- Mansimran S Loyal
Institutions
- The University of Sydney (AU)
- La Trobe University (AU)
- Department of Health and Aged Care (AU)
- UNSW Sydney (AU)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1016/j.jad.2025.01.147
- Citations
- 8
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 11.77
Funders
- National Health and Medical Research Council