Hsa-miR-532-3p protects human decidual mesenchymal stem cells from oxidative stress in recurrent spontaneous abortion via targeting KEAP1
Our study revealed a lower expression level of hsa-miR-532-3p in the hDMSCs of patients with RSA. Moreover, hsa-miR-532-3p protects hDMSCs from oxidative stress by targeting the Kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related factor 2 (KEAP1/NRF2) pathway. Hsa-miR-532-3p is closely related to gestational age and has good predictive value for identifying RSA.
Authors
- Jiaxin Zhou (ORCID: https://orcid.org/0000-0002-5172-3466)
- Ruiman Li (ORCID: https://orcid.org/0000-0003-1239-7968)
- Jinghua Pan (ORCID: https://orcid.org/0000-0003-3741-3397)
- Jing Niu (ORCID: https://orcid.org/0000-0001-6094-6162)
- Shanshan Liu (ORCID: https://orcid.org/0009-0001-2905-3283)
- Hong Zhou
Institutions
- Jinan University (CN)
- Guangdong Province Women and Children Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Redox Biology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1016/j.redox.2025.103508
- Citations
- 4
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- Jinan University
- Guangzhou Science and Technology Program key projects
- Medical Science and Technology Foundation of Guangdong Province
- Science and Technology Planning Project of Guangdong Province