Histological and genetic criteria define a clinically relevant subgroup of HPV-positive oropharyngeal carcinoma
HPV PC distinguished two histomorphological subgroups within HPV-positive OPSCCs: cHPV with excellent prognosis and non-cHPV with poorer overall survival. Non-cHPV tumors also exhibited higher overall mutation rates, notably LOF-TP53 and PIK3CA/PTEN mutations. These morphological subtypes, along with their corresponding mutational profiles, warrant further investigation as potential biomarkers for de-escalation intervention trials.
Authors
- Nora Wuerdemann
- Jörn Meinel
- Shachi Jenny Sharma (ORCID: https://orcid.org/0000-0002-2768-7936)
- Alexander Quaas (ORCID: https://orcid.org/0000-0002-9644-2115)
- Marcel Mayer (ORCID: https://orcid.org/0000-0001-9963-1109)
- Johanna Prinz
- Jannik Johannsen (ORCID: https://orcid.org/0000-0002-0947-198X)
- Christoph Arolt (ORCID: https://orcid.org/0000-0002-6366-2285)
- Janna Siemanowski (ORCID: https://orcid.org/0000-0003-2581-1320)
- Hans Nikolaus Caspar Eckel (ORCID: https://orcid.org/0000-0002-6947-9836)
- Steffen Wagner
- Charlotte Klasen (ORCID: https://orcid.org/0009-0009-3120-0439)
- Christoph Arens (ORCID: https://orcid.org/0000-0001-8072-1438)
- Jens Peter Klußmann (ORCID: https://orcid.org/0000-0002-8223-7954)
- Malte Suchan
- Christine Langer (ORCID: https://orcid.org/0000-0002-0357-2931)
- Christian U. Huebbers
- Arthur Charpentier (ORCID: https://orcid.org/0000-0001-9636-7437)
- Philipp Zimmermann (ORCID: https://orcid.org/0000-0001-9917-3662)
- Sebastian Klein
- Christopher Kopp
Institutions
- TH Köln - University of Applied Sciences (DE)
- University of Cologne (DE)
- Justus-Liebig-Universität Gießen (DE)
- Integrated Oncology (United States) (US)
- Essen University Hospital (DE)
- University Hospital Cologne (DE)
- University of Duisburg-Essen (DE)
Publication Details
- Journal
- Oral Oncology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1016/j.oraloncology.2025.107209
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00