Effect of CpG Site -123 Methylation in HOTAIR Promoter on DNMT3A Binding and Transcriptional Silencing in Endometrial Cancer

Endometrial cancer is a common malignancy with significant epigenetic alterations, particularly involving DNA methylation. The long non-coding RNA HOTAIR regulates gene expression through epigenetic mechanisms. This review investigates the specific impact of methylation at CpG site -123 within the HOTAIR promoter region on DNMT3A binding and the effects on transcriptional silencing. Understanding these interactions provides insights into HOTAIR’s epigenetic regulation and highlights potential therapeutic targets for endometrial cancer.