CONSTRUCTAL COUPLINGS IN THE ELECTROPERMEABILIZATION OF THE CELL MEMBRANE

Through electromagnetic field analysis and numerical experiments, the paper aims to explore the influence of the applied electric field frequency on the electropermeabilization (EP) conditions. The physical quantity correlated to the EP triggering is the transmembrane voltage induced before the pore generation process starts. The Constructal Law is here perceived and operates through the intrinsic couplings of the associated electromagnetic field, which may be tuned by the experiment designer, who is empowered to promote EP by adjusting the working frequency of the setup.