A rubrerythrin locus of Clostridioides difficile encodes enzymes that efficiently detoxify reactive oxygen species
The investigated gene locus codes for an oxidative stress operon whose members have the potential to neutralize O<sub>2</sub><sup>●-</sup> and H<sub>2</sub>O<sub>2</sub> to water and thus complements the arsenal of ROS detoxifying mechanisms that are already known in C. difficile. However, full activity with adequate physiological electron transfer partners still needs to be demonstrated.
Authors
- Silvia Dittmann
- Susanne Sievers (ORCID: https://orcid.org/0000-0002-5457-2552)
- Daniela Zühlke (ORCID: https://orcid.org/0000-0002-6751-9654)
- Robert Knop
- Simon Keweloh
- Johanna Pukall
Institutions
- Universitätsmedizin Greifswald (DE)
- Universität Greifswald (DE)
Publication Details
- Journal
- Anaerobe
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1016/j.anaerobe.2025.102941
- Citations
- 3
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 4.19
Funders
- Deutsche Forschungsgemeinschaft