Multimodal neuroimaging insights into the neurobiology of healthy aging across the lifespan
Our study confirms previous findings on aging and offers new insights, particularly on the role of Aβ-deposition in healthy aging. We observed a linear increase in Aβ-deposition, alongside decreases in white matter integrity, cerebral blood flow, and glucose metabolism. Additionally, we identified a complex regional relationship between Aβ-deposition, glucose metabolism, and neural communication, possibly reflecting compensatory mechanisms.
Authors
- Manouchehr Seyedi Vafaee (ORCID: https://orcid.org/0000-0001-8409-7142)
- Laust Vind Knudsen (ORCID: https://orcid.org/0000-0003-1674-3098)
- Tanja Maria Michel (ORCID: https://orcid.org/0000-0002-7181-6336)
- Ziba Ahangarani Farahani
Institutions
- University of Southern Denmark (DK)
- Odense University Hospital (DK)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1007/s00259-025-07100-w
- Citations
- 1
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- Odense Universitetshospital