β-Hydroxybutyrate-induced mitochondrial DNA (mtDNA) release mediated innate inflammatory response in bovine mammary epithelial cells by inhibiting autophagy
The findings illustrate that elevated BHB levels lead to the release of cytoplasmic mtDNA, which in turn activates the cGAS-STING pathway and triggers an inflammatory response in the mammary glands during hyperketonemia. Conversely, autophagy activation has been shown to alleviate this process by promoting cytoplasmic mtDNA degradation.
Authors
- Tianyin Feng
- Chuang Xu (ORCID: https://orcid.org/0000-0002-1163-6616)
- Ben Aernouts (ORCID: https://orcid.org/0000-0001-6266-3019)
- Yihui Huo
- Juan J. Loor (ORCID: https://orcid.org/0000-0003-1586-4365)
- Androniki Psifidi (ORCID: https://orcid.org/0000-0003-4095-1452)
- Moli Li
- Wanli Zhao
Institutions
- Royal Veterinary College (GB)
- University of Illinois Urbana-Champaign (US)
- China Agricultural University (CN)
- KU Leuven (BE)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1186/s40104-024-01143-z
- Citations
- 5
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- National Natural Science Foundation of China