NF2 loss-of-function and hypoxia drive radiation resistance in grade 2 meningiomas
NF2 LOF in the setting of hypoxia confers radiation resistance through transcriptional programs that reduce apoptosis and promote proliferation. These pathways may identify tumors resistant to radiation and represent therapeutic targets that in the future could improve LC in patients with radiation resistant G2Ms.
Authors
- Sonika M Dahiya (ORCID: https://orcid.org/0000-0002-5585-0964)
- Bhuvic Patel (ORCID: https://orcid.org/0000-0001-8062-7310)
- Kaleigh F. Roberts (ORCID: https://orcid.org/0000-0001-6483-9153)
- Joseph E. Ippolito (ORCID: https://orcid.org/0000-0003-1913-5573)
- Allegra A. Petti (ORCID: https://orcid.org/0000-0001-6884-6107)
- Albert H. Kim (ORCID: https://orcid.org/0000-0002-1751-8493)
- Namita Sinha (ORCID: https://orcid.org/0000-0002-0234-1170)
- Tiemo Jürgen Klisch (ORCID: https://orcid.org/0000-0001-8182-384X)
- Diane D. Mao
- Hsiang‐Chih Lu (ORCID: https://orcid.org/0000-0002-4927-4577)
- Collin W. English (ORCID: https://orcid.org/0000-0003-3730-2793)
- Akdes Serin Harmancı (ORCID: https://orcid.org/0000-0001-6374-9041)
- Alicia Yang
- Akash J. Patel (ORCID: https://orcid.org/0000-0002-1280-2989)
- William A. Leidig (ORCID: https://orcid.org/0009-0008-3127-3905)
- Sangami Pugazenthi (ORCID: https://orcid.org/0000-0002-5179-5232)
- Patrick DeSouza (ORCID: https://orcid.org/0000-0003-3600-4452)
- Tatenda Mahlokozera (ORCID: https://orcid.org/0000-0002-7294-9632)
- Hiroko Yano (ORCID: https://orcid.org/0000-0001-6548-0920)
- Kyle P. McGeehan (ORCID: https://orcid.org/0000-0001-5614-217X)
- Vijay Nitturi
- Shree S. Pari
Institutions
- Baylor College of Medicine (US)
- Washington University in St. Louis (US)
- Massachusetts General Hospital (US)
- Baylor School (US)
- Neurological Research Institute (US)
- Hope Center for Neurological Disorders (US)
- Texas Children's Hospital (US)
- Children's Cancer Center (US)
- Neurological Surgery (US)
- Baylor Genetics (US)
- University of Manitoba (CA)
- The University of Winnipeg (CA)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1093/jnci/djaf022
- Citations
- 3
- Primary Topic
- Meningioma and schwannoma management
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Congress of Neurological Surgeons