NF2 loss-of-function and hypoxia drive radiation resistance in grade 2 meningiomas

NF2 LOF in the setting of hypoxia confers radiation resistance through transcriptional programs that reduce apoptosis and promote proliferation. These pathways may identify tumors resistant to radiation and represent therapeutic targets that in the future could improve LC in patients with radiation resistant G2Ms.

Authors

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Publication Details

Journal
JNCI Journal of the National Cancer Institute
Published
2025-01-27
DOI
https://doi.org/10.1093/jnci/djaf022
Citations
3
Primary Topic
Meningioma and schwannoma management
Type
article
Field-Weighted Citation Impact
4.06

Funders

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article

NF2 loss-of-function and hypoxia drive radiation resistance in grade 2 meningiomas

Sonika M Dahiya, Bhuvic Patel, Kaleigh F. Roberts, Joseph E. Ippolito et al.
3 citations
JNCI Journal of the National Cancer Institute
Meningioma and schwannoma management
4.06
article

NF2 loss-of-function and hypoxia drive radiation resistance in grade 2 meningiomas

Sonika M Dahiya, Bhuvic Patel, Kaleigh F. Roberts, Joseph E. Ippolito, Allegra A. Petti, Albert H. Kim, Namita Sinha, Tiemo Jürgen Klisch, Diane D. Mao, Hsiang‐Chih Lu, Collin W. English, Akdes Serin Harmancı, Alicia Yang, Akash J. Patel, William A. Leidig, Sangami Pugazenthi, Patrick DeSouza, Tatenda Mahlokozera, Hiroko Yano, Kyle P. McGeehan, Vijay Nitturi, Shree S. Pari
article en
3 citations

Abstract

NF2 LOF in the setting of hypoxia confers radiation resistance through transcriptional programs that reduce apoptosis and promote proliferation. These pathways may identify tumors resistant to radiation and represent therapeutic targets that in the future could improve LC in patients with radiation resistant G2Ms.

JNCI Journal of the National Cancer InstituteVol. 117(6)
Baylor College of Medicine (US), Washington University in St. Louis (US), Massachusetts General Hospital (US), Baylor School (US), Neurological Research Institute (US), Hope Center for Neurological Disorders (US), Texas Children's Hospital (US), Children's Cancer Center (US), Neurological Surgery (US), Baylor Genetics (US), University of Manitoba (CA), The University of Winnipeg (CA)
Congress of Neurological Surgeons
Good health and well-being
Openalex Percentile: Top 8%
Meningioma and schwannoma management
4.06
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